Interleukin-11 Attenuates Nephrotoxic Nephritis in Wistar Kyoto Rats
نویسندگان
چکیده
منابع مشابه
Interleukin-11 attenuates nephrotoxic nephritis in Wistar Kyoto rats.
Interleukin-11 (IL-11) is a multifuctional cytokine with anti-inflammatory activity. The effect of IL-11 was studied in an experimental model of necrotizing glomerulonephritis induced in Wistar Kyoto rats by an injection of anti-glomerular basement membrane antibody (nephrotoxic serum). Intraperitoneal injection was chosen as the route of IL-11 administration in all experiments. In experiment 1...
متن کاملNephrotoxic Nephritis in Rats
Nephrotoxic anti-rat kidney sera were produced in rabbits by intraperitoneal injection of suspensions of blood-free rat kidney. The nephrotoxin of these sera could be removed by adsorption with saline suspensions of finely ground rat glomeruli, but not by adsorption with other portions of rat kidney or by adsorption with several other rat tissues. It was concluded that nephrotoxic sera of this ...
متن کاملNephrotoxic Serum Nephritis in Rats
Studies have been carried out to determine the distribution of antigen capable of inducing the formation in rabbits of antibodies nephrotoxic for the rat. The results indicate that the antigen is present both in cortex and medulla of rat kidney. It can be extracted to a limited extent with saline. It is non-dialyzable and destroyed by boiling. The nephrotoxic serum antigen is also present in ra...
متن کاملChronic nephrotoxic nephritis in spontaneously hypertensive rats.
(NTS) in Wistar rats (WR) and spontaneously hypertensive rats (SHR), our previous results suggested that sustained hypertension might aggravate the nephrotoxic processes or protract the course of glomerulonephritis. The present study was attemped to observe the more prolonged glomerular changes of nephrotoxic nephritis (NTN) until 15 weeks after the injection of NTS in SHR, compared with contro...
متن کاملBiological Variability in Wistar-Kyoto Rats
The spontaneously hypertensive rat (SHR) initially bred in Kyoto is the most widely studied animal model of essential hypertension. As controls for the SHR, most workers have used normotensive descendants of Wistar rats from the colony in Kyoto from which the SHR strain was derived (Wistar-Kyoto rats, WKY). But the presumption that WKY are serviceable controls for SHR rests on the tacit assumpt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2001
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v12112310